Epidermolysis bullosa acquisita (EBA) is rare chronic subepidermal bullous disease characterized by skin fragility, trauma-induced or spontaneous blisters, erosions, scars and milia. It is an autoimmune disease with autoantibodies to type VII
collagen.
A 54-year-old female had marked skin fragility, scatteed erythematous tense bullae, hyperpigmentations, and milia on the whole body including oral mucosa. On the histopathologic finding, the bulla showed a subepidermal cleavage and polymorphous
inflammatory cell infiltrates on the papillary dermis. On direct immunofluorescence, linear deposits of IgG and C3 were observed along the basement membrane zone. Indirect immunofluorescence technique on the saltsplit skin demonstrated linear
fluorescence only on the dermal side of the split skin.
(Kor J Dermatol 1995;33(3) : 540~545)
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